Once a person has had chickenpox, the virus lies inactive in nerve tissue. Years later, the idea may reactivate as shingles. The C.D.C. estimates which about 1 million cases are diagnosed inside the United States each year.
Given in one dose, Zostavax had shown a 51 percent reduction in shingles as well as also a 67 percent reduction in nerve pain. Shingrix is actually given in two doses, as well as also the company said clinical trials showed the idea to be about 98 percent effective for one year as well as also about 85 percent over three years.
By preventing shingles, the vaccine also drastically reduces the overall incidence of severe nerve pain, a lasting complication for about one in three people who get shingles. GlaxoSmithKline said the idea tested the vaccine in more than 38,000 people.
“We believe Shingrix will provide confidence inside the protection one can expect through a shingles vaccine,” said Luc Debruyne, the company’s president of global vaccines.
The recommendation of the advisory committee will be considered an endorsement of Shingrix over Zostavax, although the closeness of the committee vote, 8 to 7, may mitigate the market loss for Merck.
Dr. Kathleen Dooling, a medical officer inside the C.D.C.’s division of viral disease, said she expects the the agency’s final recommendation to be issued early next year.
“The Shingrix vaccine has the potential to prevent tends of thousands of cases of shingles as well as also its complications,” Dr. Dooling said.
She cautioned, however, which more people had adverse reactions to Shingrix than Zostavax, including fever as well as also muscle aches.
“Patients as well as also health care providers should be aware which This specific vaccine is actually very effective, although the idea also causes more reactions than they may be used to with additional adult vaccines,” she said. “All indications are these are not dangerous to one’s health although they may interfere with your daily activities for a few days.”
GlaxoSmithKline said its brand new vaccine might cost about $280 as well as also might be available next month. Zostavax costs about $223.
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