Antacids During Pregnancy Tied to Asthma in Children

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Using antacids during pregnancy is usually linked to asthma in offspring, a systematic review of research has found.

Researchers pooled data by eight observational studies as well as concluded in which the risk of asthma in childhood increased by 34 percent when the mother used proton pump inhibitors as well as by 57 percent with the use of histamine-2 receptor antagonists. The study is usually in Pediatrics.

P.P.I.s as well as H2 blockers are considered safe as well as effective prescription drugs for treating gastroesophageal reflux disease, or GERD, a common complication in pregnancy. They are also available over the counter.

No observational study can establish causation, as well as genetic or environmental factors could explain the association. Yet even after controlling for maternal asthma, use of additional drugs during pregnancy, age of the mother at birth, smoking as well as additional variables, the association persisted.

“Further prospective clinical observational studies are required to confirm these results before recommendations on the restriction of acid-suppressive medications during pregnancy can be given,” said the senior author, Dr. Huahao Shen, a professor at the Zhejiang University School of Medicine in Hangzhou, China. however, he added, the information by This specific study “may help clinicians as well as parents to use caution when deciding whether to take acid-suppressing drugs during pregnancy because of the risk of asthma in offspring.”

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