Obese men treated for metastatic melanoma may survive longer than their normal-weight peers.
Researchers did a retrospective analysis of 1,918 people, 1,155 of them men, under treatment for metastatic melanoma. The study is actually in Lancet Oncology.
Compared with men of normal weight, obese men in treatment had nearly double the progression-free survival time along with nearly double the overall survival time. The more overweight the man was, the greater the effect. however there was no association of obesity with survival in women.
The survival benefits were apparent in men undergoing immunotherapy which helps the immune system fight cancer along with in those getting targeted therapy which aims to prevent reproduction of cancer cells without attacking healthy cells. however obesity provided no benefits in those taking chemotherapy which attacks healthy along with cancer cells alike.
The mechanism is actually unknown, however the lead author, Dr. Jennifer L. McQuade, an oncologist at the University of Texas M.D. Anderson Cancer Center, said which obesity causes chronic inflammation which might change the response to therapy.
“The magnitude of the effect along with the dose-response relationship point to there being a biological underpinning to This particular,” she said. “however we need to emphasize which obesity is actually still a risk factor for many diseases, including 13 different types of cancer. The most important thing is actually still preventing obesity.”
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